@article{ref1,
title="Is procalcitonin a marker of critical illness in heatstroke?",
journal="Intensive care medicine",
year="2008",
author="Hausfater, Pierre and Hurtado, Margarita and Pease, Sebastian and Juillien, Gaëlle and Lvovschi, Virginie-Eve and Salehabadi, Sepehr and Lidove, Olivier and Wolff, Michel and Bernard, Maguy and Chollet-Martin, Sylvie and Riou, Bruno",
volume="34",
number="8",
pages="1377-1383",
abstract="OBJECTIVE: To study the effect of non-exertional heatstroke on serum procalcitonin (PCT) levels. DESIGN: Cohort study. SETTING: The emergency and intensive care departments of two academic tertiary-care hospitals, Paris, France PATIENTS: A total of 53 patients with defined heatstroke attending the emergency department and/or the intensive care unit during the August 2003 heat wave in France. INTERVENTIONS: None. MEASUREMENTS: Serum PCT measurement using a sensitive assay and vital and routine biological variables on arrival of patients presenting with classic heatstroke. Thirty-day mortality was recorded. RESULTS: Among the 53 patients included, 14 (26%) were admitted to an intensive care unit (ICU). At 30 days, 24 patients (45%) had died. Median PCT value was 0.58 microg/l (95% confidence interval 0.16-1.61) and 31 (58%) patients had PCT above 0.2 microg/l (PCT+). Temperature above or equal to 40 degrees C was the only variable significantly associated with fatal outcome. Median PCT values were 1.4 microg/l (0.16-4.71) and 0.18 microg/l (0.12-1.61) in the group of deceased and surviving patients respectively (p = 0.22). All patients admitted in ICU had elevated PCT values. Patients PCT+ initially presented with a more pronounced systemic inflammatory response. Microbiologically or clinically documented infection was not more frequent in PCT+ group. CONCLUSION: High serum PCT levels can be observed in heatstroke without any concomitant documented bacterial infection. The PCT is not a valid mortality predictor in heatstroke but could be an indicator of the severity of illness. Heatstroke could represent a model of a &quot;non-septic&quot; pathway of PCT synthesis.<p /><p>Language: en</p>",
language="en",
issn="0342-4642",
doi="10.1007/s00134-008-1083-y",
url="http://dx.doi.org/10.1007/s00134-008-1083-y"
}