@article{ref1,
title="Antidepressant-related deaths and antidepressant prescriptions in England and Wales, 1998-2000",
journal="British journal of psychiatry",
year="2004",
author="Cheeta, Survjit and Schifano, Fabrizio and Oyefeso, Adenekan and Webb, Lucy and Ghodse, A. Hamid",
volume="184",
number="",
pages="41-47",
abstract="BACKGROUND: Deaths from antidepressants continue to account for a substantial proportion of drug-related deaths. AIMS: To investigate the relative toxicity of the major classes of antidepressant drugs, with the specific objective of assessing this in relation to the cause of death; and to analyse the deaths where there were multiple mentions of antidepressant drugs or other psychoactive drugs with antidepressants. METHOD: Mortality data were collected from the National Programme of Substance Abuse Deaths, and antidepressant prescription data were collected. RESULTS: Most deaths from antidepressant drugs were suicides (80%). Tricyclic antidepressants (TCAs) accounted for more drug mentions than did other antidepressant drugs (12 per million prescriptions). Selective serotonin reuptake inhibitors (SSRIs) were associated with a significantly lower risk of toxicity, but 93% of deaths from SSRIs occurred in combination with other drugs, especially TCAs (24.5%). In 'combination' deaths patients were significantly more likely to have had a history of drug misuse. CONCLUSIONS: The efficacy and safety of augmentation therapy with TCAs in SSRI-resistant patients should be monitored carefully, and patients prescribed antidepressants should be screened for drug use/misuse.<p /><p>Language: en</p>",
language="en",
issn="0007-1250",
doi="",
url="http://dx.doi.org/"
}