@article{ref1,
title="Gene and protein alterations of FKBP5 and glucocorticoid receptor in the amygdala of suicide victims",
journal="Psychoneuroendocrinology",
year="2013",
author="Pérez-Ortiz, José M. and García-Gutiérrez, María S. and Navarrete, Francisco and Giner, Salvador and Manzanares, Jorge",
volume="38",
number="8",
pages="1251-1258",
abstract="Recent reports suggest that FKBP5 gene and its corresponding FKBP5 protein play a relevant role in the regulation of anxiety and depression in animal models and human stress-related disorders. In the present study, FKBP5 and glucocorticoid receptor (GR) gene and protein expression were analyzed in the amygdala (AMY) of suicide victims (n=13 males, without clinical psychiatric history and non-treated with anxiolytic or antidepressant drugs) and its corresponding controls (n=13 males) by real-time PCR and Western blotting. The results revealed that FKBP5 and GR gene expression were significantly reduced in the AMY (-38% and -48%, respectively) of suicide victims compared with controls. Interestingly, FKBP5 and GR protein expression were also significantly decreased (-41% and -42%, respectively) in the AMY of suicide victims compared with controls. These results suggest that the FKBP5 plays a relevant role in human emotional responses and suggest this receptor as a new promising target in the treatment of suicide behavior.<p /> <p>Language: en</p>",
language="en",
issn="0306-4530",
doi="10.1016/j.psyneuen.2012.11.008",
url="http://dx.doi.org/10.1016/j.psyneuen.2012.11.008"
}