@article{ref1,
title="Fatal metformin intoxication with markedly elevated blood and liver concentrations",
journal="Journal of analytical toxicology",
year="2012",
author="Cantrell, F. Lee and Nelson, Craig L. and Gary, Ray D. and McIntyre, Iain M.",
volume="36",
number="9",
pages="657-659",
abstract="Metformin (Glucophage) is a medication used to treat Type 2 diabetes. The highest postmortem metformin concentrations are recorded utilizing a sensitive and specific analytical procedure. The peripheral blood metformin concentration was 240 mg/L, the liver concentration was 240 mg/kg and the gastric concentration was 1,700 mg. Additionally, an antemortem blood sample collected shortly after admission revealed a metformin concentration of 210 mg/L. These data, revealing a liver to peripheral blood ratio of 1.0, provide additional support that metformin is not subject to postmortem redistribution. Intentional self-poisonings with metformin can result in death, despite multiple medical interventions.<p /> <p>Language: en</p>",
language="en",
issn="0146-4760",
doi="10.1093/jat/bks076",
url="http://dx.doi.org/10.1093/jat/bks076"
}