@article{ref1,
title="Role of mother's genes and environment in postpartum depression",
journal="Proceedings of the National Academy of Sciences of the United States of America",
year="2011",
author="Mitchell, Colter and Notterman, Daniel and Brooks-Gunn, Jeanne and Hobcraft, John and Garfinkel, Irwin and Jaeger, Kate and Kotenko, Iulia and McLanahan, Sara",
volume="108",
number="20",
pages="8189-8193",
abstract="Most studies of human molecular genetics and social environment interactions on health have relied heavily on the classic diathesis-stress model that treats genetic variations and environments as being either &quot;risky&quot; or &quot;protective.&quot; The biological susceptibility model posits that some individuals have greater genetic reactivity to stress, leading to worse outcomes in poor environments, but better outcomes in rich environments. Using a nontruncated measure of a chronic environmental stressor--socioeconomic status--measured by education, and two polymorphisms (5-HTTLPR and STin2 VNTR) of the serotonin transporter gene (5-HTT), we find strong evidence that some women are genetically more reactive to the environment, resulting in a crossover of risks of postpartum depression for the most reactive groups. We discuss how our approach and findings provide a framework for understanding some of the confusion in the gene-environment interaction literature on stress, 5-HTT, and depression.<p /><p>Language: en</p>",
language="en",
issn="0027-8424",
doi="10.1073/pnas.1014129108",
url="http://dx.doi.org/10.1073/pnas.1014129108"
}