@article{ref1,
title="Relationship between release of beta-endorphin, cortisol, and trauma severity in children with blunt torso and extremity trauma",
journal="Journal of trauma",
year="2007",
author="Muhtaroğlu, Sabahattin and Ozokutan, Bülent Hayri and Küçükaydn, Mustafa and Okur, Hamit and Kazez, Ahmet and Turan, Cüneyt",
volume="62",
number="2",
pages="320-4; discussion 324",
abstract="PURPOSE: To determine the levels of beta-endorphin and cortisol in children with multiple injuries and to determine whether there is any difference between and compare the severity of trauma and beta-endorphin and cortisol release as calculated using Pediatric Trauma Score (PTS). METHODS: During a 10-month period, 80 children with multiple injuries admitted to a University Hospital's Pediatric Surgery Department were studied. Blood samples were obtained immediately at admission and a PTS of each patient was calculated. The correlation between PTS and hormonal values were searched. The children were classified into two groups according to their PTS. Group 1 had PTS >8 and group 2 had PTS < or =8. The two groups were also compared with respect to their beta-endorphin and cortisol values. RESULTS: There was a linear correlation between beta-endorphin and cortisol values and the injury severity. The levels were higher in the patients with more severe injuries. There were 60 patients in group 1 and 20 patients in group 2. Their ages were 9.2 +/- 4.1 and 9.7 +/- 4.2 years, respectively (p > 0.05). The mean PTS for group 1 patients was 11 +/- 0.8 and for group 2 patients was 7.4 +/- 1.2 (p < 0.001). The mean plasma beta-endorphin concentrations were 124.4 +/- 114.4 pg/mL in group 1 patients and 261.6 +/- 231.2 pg/mL in group 2 (p < 0.001). The respective plasma cortisol concentrations in the two groups were 22.5 +/- 10.3 microg/dL and 30.8 +/- 17.2 microg/dL (p < 0.05), respectively. CONCLUSIONS: The results of this study show that the plasma beta-endorphin and cortisol levels are elevated in children after blunt trauma and the degree of elevation is related to the injury severity.<p /><p>Language: en</p>",
language="en",
issn="0022-5282",
doi="10.1097/01.ta.0000222714.91463.a3",
url="http://dx.doi.org/10.1097/01.ta.0000222714.91463.a3"
}