@article{ref1,
title="Design and validation of a highly discriminatory 10-locus Y-chromosome STR multiplex system",
journal="Forensic science international: genetics",
year="2011",
author="D'Amato, M.E. and Bajic, V.B. and Davison, S.",
volume="5",
number="2",
pages="122-125",
abstract="The Y-chromosome STRs (short tandem repeat) markers are routinely utilized in the resolution of forensic casework related to sexual assault. For this, the forensic community has adopted a set of eleven (core) Y-STR that is incorporated in all commercial diagnostic systems. Our previous studies of Y-STR polymorphisms in the South African population identified low levels of diversity and discrimination capacity for many commercial marker sets, determining a limited applicability of these systems to the local population groups. To overcome this shortcoming, we designed a Y-STR 10-plex system that shows higher discriminatory capacity (DC) than available commercial systems. The markers were selected from a population group of 283 individuals with African, European and Asian ancestry genotyped at 45 Y-STRs, applying an optimization based selection procedure to achieve the highest possible DC with the minimal number of markers. The 10-plex was satisfactorily subjected to developmental validation tests following the SWGDAM guidelines and shows potential for its application to genealogical and evolutionary studies.<p />",
language="",
issn="1872-4973",
doi="10.1016/j.fsigen.2010.08.015",
url="http://dx.doi.org/10.1016/j.fsigen.2010.08.015"
}