@article{ref1,
title="Promising strategies to minimize secondary brain injury after head trauma",
journal="Critical care medicine",
year="2003",
author="Bayir, Hulya and Clark, Robert S. B. and Kochanek, Patrick Michael",
volume="31",
number="1 Suppl",
pages="S112-7",
abstract="OBJECTIVE: To review novel therapeutic approaches in the treatment of severe traumatic brain injury. DESIGN: Eighty-three studies were reviewed specific to the treatment of traumatic brain injury, in either experimental models or in patients. CONCLUSION: Four therapeutic strategies appear to be the most promising approaches currently in clinical trials for severe traumatic brain injury: a) the novel pharmacologic agent dexanabinol; b) hypertonic saline; c) mild hypothermia; and d) decompressive craniectomy. Each of these therapies share the common feature of targeting multiple mechanisms, suggesting this may be an important factor to the development of a successful approach to severe traumatic brain injury.<p /><p>Language: en</p>",
language="en",
issn="0090-3493",
doi="10.1097/01.CCM.0000042464.46603.0E",
url="http://dx.doi.org/10.1097/01.CCM.0000042464.46603.0E"
}