@article{ref1,
title="Antidepressants and the risk of bleeding",
journal="Tijdschrift voor Psychiatrie",
year="2012",
author="Küçükaycan, M. and Van Den Eede, F. and Moreels, T. and Sabbe, Bernard G. C.",
volume="54",
number="3",
pages="225-234",
abstract="<span class=&quot;subtitle&quot;>background </span>By blocking the serotonin transporter system antidepressants can, in theory, result in bleedings. However, we do not yet know how great the risk of bleeding is and what the clinical implications are. <span class=&quot;subtitle&quot;>aim </span>To assess how great the risk of bleeding is and what the clinical implications are. <span class=&quot;subtitle&quot;>method</span> Using keywords ‘antidepressants’ and ‘bleeding’ we searched the relevant literature up to March 2011 to find out what the risk of bleeding were for users of antidepressants. <span class=&quot;subtitle&quot;>results</span> 34 studies met our selection criteria. Most studies reported upper gastrointestinal bleeding and hemorrhagic cerebrovascular accidents <span class=&quot;abbreviation&quot;>(cva</span>). Antidepressants with high serotonin affinity can slightly increase the risk of upper gastrointestinal bleeding. Antidepressants do not increase the risk for hemorrhagic <span class=&quot;abbreviation&quot;>cva</span>. Very little information is available about other types of bleeding. <span class=&quot;subtitle&quot;>conclusion </span>Our systematic review of the literature shows that antidepressants are relatively safe as far as bleeding is concerned. Precautions can be taken in the case of high risk patients.<p /> <p>Language: nl</p>",
language="nl",
issn="0303-7339",
doi="",
url="http://dx.doi.org/"
}