@article{ref1,
title="Long-lasting sensitization to the accelerating effects of amphetamine on the speed of an internal clock",
journal="Behavioural brain research",
year="1999",
author="Badiani, A. and Stewart, J.",
volume="100",
number="1-2",
pages="217-223",
abstract="Drinking in the rat occurs in bursts of rapid licking, a high frequency rhythmic behavior controlled by a neural clock located in the brain stem. We found that 3.0 mg/kg amphetamine increased the speed of licking and shifted to the left the frequency distribution of inter-lick intervals. Repeated amphetamine treatments result in long-lasting sensitization to this effect. Thus, it appears possible to produce enduring changes in the activity of a biological interval clock (or 'stopwatch') by manipulating catecholaminergic transmission. These findings may be important for an understanding of the neural basis of normal and pathological timing behavior.<p /><p>Language: en</p>",
language="en",
issn="0166-4328",
doi="",
url="http://dx.doi.org/"
}