@article{ref1,
title="Pathways of muscle protein breakdown in injury and sepsis",
journal="Current opinion in clinical nutrition and metabolic care",
year="1999",
author="Hasselgren, P. O.",
volume="2",
number="2",
pages="155-160",
abstract="The purpose of this article is to review evidence that the ubiquitin-proteasome proteolytic pathway plays an important role in injury- and sepsis-induced muscle catabolism. Such evidence includes upregulated gene expression of several of the components of the ubiquitin-proteasome pathway as well as energy-dependency of the injury- and sepsis-induced muscle protein breakdown. Although the ubiquitin-proteasome pathway is the predominant mechanism of muscle breakdown in various catabolic conditions, other proteolytic mechanisms, in particular calcium-dependent, calpain-mediated protein degradation, probably participate as well.<p /><p>Language: en</p>",
language="en",
issn="1363-1950",
doi="",
url="http://dx.doi.org/"
}