@article{ref1,
title="Measurement of lactic acid in multiple injury patients and its usefulness as a predictor of multiorgan failure and mortality",
journal="Cirugia Espanola",
year="2012",
author="Montmany Vioque, Sandra and Navarro Soto, Salvador and Rebasa Cladera, Pere and Luna Aufroy, Alexis and Gómez Díaz, Carlos and Llaquet Bayo, Heura",
volume="90",
number="2",
pages="107-113",
abstract="INTRODUCTION: The use of lactic acid as marker of occult hyperfusion and its relationship with multiorgan failure (MOF) and/or mortality is a subject of debate. MATERIAL AND METHOD: A prospective study was conducted on multiple injury patients over 16 years of age in critical care areas. The lactic acid was measured at the beginning and at 24hours of the trauma and associating it with the patient morbidity and mortality. RESULTS: A total of 342 patients, with a mean injury severity score of 24.1, were included. The patients who survived had an initial, and 24hours after the trauma, lactic acid of 27.8mg/dl and 17.9mg/dl, respectively, (normal values less than 22mg/dl), increasing to 36.5mg/dl and 40.2mg/dl, respectively, in those who died. There were no differences between the initial lactic acid in patients with and without MOF, being increased at 24hours in those who had MOF (17.8 vs 26.7). The patients with a lactic acid that got worse or remained abnormal at 24hours had a higher mortality than those in which it remained the same or improved (25% - 17.1% vs 6.3% - 0.8%), with the percentage of patients with MOF also increasing (40.6% - 32.8% vs 14.9% - 11.1%). In haemodynamically stable patients, there was also a higher mortality when the lactic acid got worse or remained abnormal in the first 24hours (23.8% - 19.2% vs 8.8% - 0%), as well as a higher percentage of MOF (38.1% - 26.9% vs 10.9% - 7.6%). CONCLUSIONS: The lactic acid results in the first 24hours of the multiple injury patient are associated with mortality and MOF, even when the patient is haemodynamically stable.<p /> <p>Language: es</p>",
language="es",
issn="0009-739X",
doi="10.1016/j.ciresp.2011.07.011",
url="http://dx.doi.org/10.1016/j.ciresp.2011.07.011"
}