@article{ref1,
title="Sex dependent toxicity of four chemicals",
journal="Research communications in chemical pathology and pharmacology",
year="1975",
author="Toth, B. and Shimizu, H. and Sornson, H. and Issenberg, P. and Erickson, J.",
volume="10",
number="3",
pages="577-580",
abstract="Toxicity investigations were conducted with 4 chemicals: hydrazine, 1,2-dimethylhydrazine di HCl, phenylhydrazine HCl and Beta-N-(gamma-L(+)-glutamyl)-4-hydroxymethylphenylhydrazine in Swiss mice. Hydrazine and phenylhydrazine HCl were administered daily in drinking water, the former at 0.01% and the latter at 0.001% concentrations. The 1,2-dimethylhydrazine di HCl and Beta-N-(gamma-L(+)-glutamyl)-4-hydroxymethylphenylhydrazine were given as a single subcutaneous injection at 45 mug and 100 mug/gr. body weight basis, respectively. The findings clearly showed that all four chemicals exerted a stronger toxic effect in male than in female mice. It is, therefore, recommended in similar situations to use different doses of chemicals for each sex in the long-term tumorigenesis studies.<p /><p>Language: en</p>",
language="en",
issn="0034-5164",
doi="",
url="http://dx.doi.org/"
}