@article{ref1,
title="Psychosocial problems and recruitment of incentive neurocircuitry: Exploring individual differences in healthy adolescents",
journal="Developmental cognitive neuroscience",
year="2011",
author="Bjork, James M. and Smith, Ashley R. and Chen, Gang and Hommer, Daniel W.",
volume="1",
number="4",
pages="570-577",
abstract="Maturational differences in brain responsiveness to rewards have been implicated in the increased rates of injury and death in adolescents from behavior-related causes. However, much of this morbidity is related to drug intoxication or other externalizing behaviors, and may be concentrated in a subset of adolescents who are at psychosocial or neurobiological risk. To examine whether individual differences in psychosocial and behavioral symptomatology relate to activation of motivational neurocircuitry, we scanned 26 psychiatrically-healthy adolescents using fMRI as they performed a monetary incentive delay task. Overall Problem Density on the Drug Use Screening Inventory (DUSI-OPD) correlated positively with activation of ventral mesofrontal cortex (mFC) during anticipation of responding for rewards (versus responding for no incentive). In addition, DUSI-OPD also correlated positively with right ventral striatum recruitment during anticipation of responding to win rewards (versus responding for no incentive or to avoid losses of identical magnitudes). Finally, a psychophysiological interaction (PPI) analysis indicated that increased connectivity between nucleus accumbens and portions of anterior cingulate and mFC as a function of reward prospects also correlated with DUSI-OPD. These findings extend previous reports demonstrating that in adolescents, individual differences in reactivity of motivational neurocircuitry relate to different facets of impulsivity or externalizing behaviors.<p /> <p>Language: en</p>",
language="en",
issn="1878-9293",
doi="10.1016/j.dcn.2011.07.005",
url="http://dx.doi.org/10.1016/j.dcn.2011.07.005"
}