@article{ref1,
title="Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims",
journal="Journal of psychiatric research",
year="2012",
author="Pandey, Ghanshyam N. and Rizavi, Hooriyah S. and Ren, Xinguo and Fareed, Jawed and Hoppensteadt, Debra A. and Roberts, Rosalinda C. and Conley, Robert R. and Dwivedi, Yogesh",
volume="46",
number="1",
pages="57-63",
abstract="Teenage suicide is a major public health concern, but its neurobiology is not well understood. Proinflammatory cytokines play an important role in stress and in the pathophysiology of depression-two major risk factors for suicide. Cytokines are increased in the serum of patients with depression and suicidal behavior; however, it is not clear if similar abnormality in cytokines occurs in brains of suicide victims. We therefore measured the gene and protein expression levels of proinflammatory cytokines interleukin (IL)-1β, IL-6, and tissue necrosis factor (TNF)-α in the prefrontal cortex (PFC) of 24 teenage suicide victims and 24 matched normal control subjects. Our results show that the mRNA and protein expression levels of IL-1β, IL-6, and TNF-α were significantly increased in Brodmann area 10 (BA-10) of suicide victims compared with normal control subjects. These results suggest an important role for IL-1β, IL-6, and TNF-α in the pathophysiology of suicidal behavior and that proinflammatory cytokines may be an appropriate target for developing therapeutic agents.<p /> <p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2011.08.006",
url="http://dx.doi.org/10.1016/j.jpsychires.2011.08.006"
}