@article{ref1,
title="Hemostatic changes due to the venom gland extract of the red-necked keelback snake (Rhabdophis subminiatus)",
journal="Toxicon: Journal of the International Society on Toxinology",
year="1991",
author="Zotz, R. B. and Mebs, D. and Hirche, H. and Paar, D.",
volume="29",
number="12",
pages="1501-1508",
abstract="After a bite by the aglyphous red-necked keelback snake Rhabdophis subminiatus a complete defibrinogenation syndrome with severe hemorrhagic diathesis developed in a 25-year-old man. In vitro studies showed that the venom gland extract of the snake contains a very active prothrombin (Factor II) activator. The thrombin generated is inhibited neither by antithrombin III nor the antithrombin-III-heparin complex. The venom gland extract stimulated also the tissue plasminogen activator; however, it did not cause direct activation of plasminogen, protein C, Factor X or direct degradation of fibrinogen.<p /><p>Language: en</p>",
language="en",
issn="0041-0101",
doi="",
url="http://dx.doi.org/"
}