@article{ref1,
title="Biphasic time-course of serum concentrations of clomipramine and desmethylclomipramine after a near-fatal overdose",
journal="Veterinary and human toxicology",
year="1994",
author="Dale, O. and Hole, A.",
volume="36",
number="4",
pages="309-310",
abstract="A 27-y-old male was admitted deeply comatosed 5-6 h after taking approximately 15 g clomipramine. The prominent feature of the case was a biphasic course of clomipramine and desmethylclomipramine serum concentrations, possibly caused by delayed drug absorption. Clinically, 2 serious episodes requiring mechanical ventilation and aggressive pressor agent infusions occurred as the serum concentrations declined. However, the severe adult respiratory distress syndrome--related inflammatory process that required 4 w of intensive care may also be an explanation, although blood cultures were negative and neither liver nor renal functions were severely compromised.<p /><p>Language: en</p>",
language="en",
issn="0145-6296",
doi="",
url="http://dx.doi.org/"
}