@article{ref1,
title="Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis",
journal="Hepatology",
year="2008",
author="Maher, Jacquelyn J. and Leon, Pablo and Ryan, James C.",
volume="48",
number="2",
pages="670-678",
abstract="Obesity is an inflammatory disorder characterized by heightened activity of the innate immune system. Innate immune activation is central to the development of obesity-related insulin resistance; it also plays an important role in obesity-related tissue damage, such as that seen in atherosclerosis. Recent research has implicated the innate immune system in the pathophysiology of obesity-related liver disease. This review summarizes how innate immune processes, occurring both within and outside the liver, cause not only insulin resistance but also end-organ damage in the form of nonalcoholic fatty liver disease. (HEPATOLOGY 2008;48:670–678.)<p />",
language="",
issn="0270-9139",
doi="10.1002/hep.22399",
url="http://dx.doi.org/10.1002/hep.22399"
}