@article{ref1,
title="A One‐Pot Synthesis of Constitutionally Unsymmetrical Rotaxanes Using Sequential CuI‐Catalyzed Azide–Alkyne Cycloadditions",
journal="Chemistry: a European journal",
year="2008",
author="Spruell, Jason M and Dichtel, William R and Heath, James R and Stoddart, J.  Fraser",
volume="14",
number="14",
pages="4168-4177",
abstract="A one-pot sequential CuI-catalyzed azide–alkyne cycloaddition (CuAAC) strategy is presented for the synthesis of constitutionally unsymmetrical cyclobis(paraquat-p-phenylene)-based rotaxanes in good yields from simple starting materials. The methodology consists of performing multiple CuAAC reactions to stopper a pseudorotaxane in a stepwise manner, the order of which is controlled through silyl-protection and AgI-catalyzed deprotection of a terminal alkyne. The methodology is highlighted by the synthesis of an amphiphilic branched [4]rotaxane. The methodology increases the ability to access ever more complicated mechanically interlocked compounds to serve in devices as sophisticated and functional molecular machinery.<p />",
language="",
issn="0947-6539",
doi="10.1002/chem.200800067",
url="http://dx.doi.org/10.1002/chem.200800067"
}