@article{ref1,
title="Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disorders",
journal="Journal of clinical psychiatry",
year="2004",
author="Steiger, Howard and Gauvin, Lise and Israël, Mimi and Kin, N. M. K. Ng Ying and Young, Simon N. and Roussin, Julie",
volume="65",
number="6",
pages="830-837",
abstract="BACKGROUND: Across populations, findings associate impulsivity, behavioral disinhibition, or hostility with reduced central serotonin (5-hydroxytryptamine: 5-HT) activity and increased likelihood of childhood abuse. Inconsistently, findings associate compulsivity, behavioral inhibition, or anxiousness with elevated 5-HT neurotransmission. We explored relationships among measures of 5-HT system functioning, behavioral inhibition/disinhibition, and childhood abuse in women with bulimia-spectrum eating syndromes. METHOD: In 73 bulimic (body mass index [kg/m2] under 30, binge eating at least once weekly) and 50 normal-eater control women, we obtained indices of platelet paroxetine binding and 5-HT agonist (m-CPP)-stimulated neuroendocrine responses. Cluster analysis was used to classify the bulimic women according to 5-HT &quot;profiles.&quot; Resulting groups were then compared on symptom and trait measures. RESULTS: Measures of paroxetine-binding density (Bmax) and affinity (Kd) contributed significantly (p < .001 and p < .02, respectively) to a classification of bulimic women into groups with &quot;low density/high affinity&quot; (N = 52) or &quot;high density/low affinity&quot; (N = 21) binding. The 5-HT based classification did not predict eating-symptom severity. However, the &quot;high density&quot; pattern was associated with increased perfectionism and compulsivity, reduced risk of childhood sexual abuse, and (to some extent) reduced probability of borderline personality disorder. DISCUSSION: In women with bulimic syndromes, serotonergic factors, personality-trait variations, and developmental typologies converge in principled fashion. Our findings corroborate (with neurobiological evidence) the concept of underregulated and overregulated subtypes within the bulimic population.<p /><p>Language: en</p>",
language="en",
issn="0160-6689",
doi="",
url="http://dx.doi.org/"
}