@article{ref1,
title="Suicide attempts and the tryptophan hydroxylase gene",
journal="Molecular psychiatry",
year="2001",
author="Abbar, M. and Courtet, Philippe and Bellivier, F. and Leboyer, M. and Boulenger, Jean-Philippe and Castelhau, D. and Ferreira, M. and Lambercy, C. and Mouthon, D. and Paoloni-Giacobino, A. and Vessaz, M. and Malafosse, A. and Buresi, C.",
volume="6",
number="3",
pages="268-273",
abstract="Tryptophan hydroxylase (TPH) is the rate-limiting enzyme of serotonin synthesis. In this case-control study, we investigated whether the TPH gene was a susceptibility factor for suicidal behavior. Seven polymorphisms spanning the entire gene were studied in a case-control study including 231 individuals who had attempted suicide and 281 controls. Significant associations were found between variants in introns 7, 8 and 9 (chi(2) = 11.2, df = 1, P< 0.0008 for the allele distribution; these loci are in complete linkage disequilibrium) and in the 3' noncoding region (chi(2) = 30.94, P = 0.0014) and suicide attempt. The association was strongest for subjects who had attempted suicide by violent means and who had a history of major depression. No significant association was observed between suicide attempts and polymorphisms in the promoter, intron 1 and intron 3. The results presented here, and those of previous studies, suggest that a genetic variant of the 3' part of the TPH gene may be a susceptibility factor for a phenotype combining suicidal behavior, mood disorder and impulsive aggression.<p /><p>Language: en</p>",
language="en",
issn="1359-4184",
doi="10.1038/sj.mp.4000846",
url="http://dx.doi.org/10.1038/sj.mp.4000846"
}