@article{ref1,
title="Differential effect of Fyn tyrosine kinase deletion on offensive and defensive aggression",
journal="Behavioural brain research",
year="2001",
author="Miyakawa, T. and Yagi, T. and Takao, K. and Niki, H.",
volume="122",
number="1",
pages="51-56",
abstract="Fyn tyrosine kinase is highly expressed in the limbic system and mice lacking Fyn tyrosine kinase showed increased fearfulness in a variety of tests for anxiety-related behaviors. To investigate the possible role of Fyn tyrosine kinase in aggression, we assessed the aggressive behaviors of the mice lacking the Fyn tyrosine kinase using the resident-intruder and restraint-induced target biting paradigms. The percentage of Fyn-deficient mice that attacked an inanimate target in a restraint tube was higher than that of the control mice. On the contrary, in the resident-intruder paradigm, the percentage of Fyn-deficient mice that attacked the intruder was lower and the Fyn-deficient mice showed a longer latency to attack an intruder. These results suggest a distinct role of Fyn tyrosine kinase in enhancing the offensive aggression and decreasing the defensive aggression. A possible influence of anxiety-phenotype of the Fyn-deficient mice on their abnormal aggressive behavior was discussed.<p /><p>Language: en</p>",
language="en",
issn="0166-4328",
doi="",
url="http://dx.doi.org/"
}