@article{ref1,
title="Morphine withdrawal-facilitated aggression is attenuated by morphine-conditioned stimuli",
journal="Pharmacology, biochemistry, and behavior",
year="2001",
author="Sukhotina, I. A.",
volume="68",
number="1",
pages="93-98",
abstract="There is a considerable body of evidence indicating that stimuli associated with drug administration may become conditioned and evoke drug-like effects. The purpose of this study was to evaluate the ability of morphine-paired stimuli to affect an expression of morphine withdrawal-facilitated aggression. Individually housed aggressive adult mice were subjected to the repeated subcutaneous administration of morphine (twice a day, 8 days, increasing doses 10-80 mg/kg). Morphine treatment cessation facilitated an aggressive behaviour of animals during the second day of withdrawal. Subcutaneous but not intraperitoneal injection of saline attenuated the aggressive behaviour in morphine-withdrawn mice. These results suggest that the site of drug injection may serve as a conditioned stimulus.<p /><p>Language: en</p>",
language="en",
issn="0091-3057",
doi="",
url="http://dx.doi.org/"
}