@article{ref1,
title="Association of a functional variant of neuronal nitric oxide synthase gene with self-reported impulsiveness, venturesomeness and empathy in male offenders",
journal="Journal of neural transmission",
year="2010",
author="Retz, Wolfgang and Reif, Andreas and Freitag, Christine M. and Retz-Junginger, Petra and Rösler, Michael",
volume="117",
number="3",
pages="321-324",
abstract="It has been shown that a functional promoter dinucleotide repeat length variation of the neuronal nitric oxide synthase gene (NOS1 Ex1f-VNTR) is associated with impulsivity-related behavioral phenotypes. In this study, the Eysenck Impulsivity Questionnaire (IVE-7) was administered to 182 male offenders to prove the hypothesis that NOS1 Ex1f-VNTR is associated with self-reported impulsiveness, venturesomeness and empathy. Multivariate analysis of variance (MANCOVA) revealed a significant multivariate effect of NOS1 Ex1f-VNTR genotype on IVE-7 measures (P = 0.0006). The effect was more pronounced regarding impulsiveness and empathy (P = 0.0052 and P = 0.0036, respectively) as compared with venturesomeness, which was only of borderline significance. The findings give additional evidence that NOS-I is involved in the regulation of impulsive personality traits and support the notion that the NOS1 gene takes part in the regulation of social behavior.<p /> <p>Language: en</p>",
language="en",
issn="0300-9564",
doi="10.1007/s00702-009-0352-4",
url="http://dx.doi.org/10.1007/s00702-009-0352-4"
}