@article{ref1,
title="Suicidal behaviors and the tryptophan hydroxylase gene",
journal="Archives of general psychiatry",
year="1995",
author="Abbar, M. and Courtet, Philippe and Amadéo, S. and Caer, Y. and Mallet, J. and Baldy-Moulinier, M. and Castelnau, D. and Malafosse, A.",
volume="52",
number="10",
pages="846-849",
abstract="BACKGROUND: To determine whether the tryptophan hydroxylase gene (ie, the gene that codes for the rate-limiting enzyme in the metabolic pathway of serotonin) may be a susceptibility factor for suicidal behavior. METHODS: Genotypic and allelic frequencies at a polymorphic Ava II restriction site were revealed with the use of the complementary DNA tryptophan hydroxylase probe C2-38 in 62 suicide attempters. The psychiatric characteristics of these suicide attempters were determined using the Schedule for Affective Disorders and Schizophrenia-Lifetime version with modification for the study of anxiety disorders, and these characteristics were compared with those in 52 healthy controls. RESULTS: No association between tryptophan hydroxylase and suicidal behavior was detected. CONCLUSION: The tryptophan hydroxylase gene was not a susceptibility factor for suicidal behaviors in the group of suicide attempters in this study.<p /><p>Language: en</p>",
language="en",
issn="0003-990X",
doi="",
url="http://dx.doi.org/"
}