@article{ref1,
title="Head injury and the risk of Alzheimer's disease: a case control study",
journal="International journal of geriatric psychiatry",
year="1997",
author="Salib, Emad and Hillier, V.",
volume="12",
number="3",
pages="363-368",
abstract="OBJECTIVES: The objective of this study is to examine the association between Alzheimer's disease and head injury in elderly patients referred to an EMI unit. METHOD: An unmatched case control study comparing 198 cases of Alzheimer's disease (NINCDS-ADRDA diagnostic criteria) to selected controls (164 other dementias and 176 non-dementing group) with respect to history of head trauma, with or without loss of consciousness, prior to the onset of dementia. SETTING: EMI unit in Warrington serving an elderly population of 28,000. The subjects included all patients referred to and seen by the first author during a 2-year study period 1991-1993. MAIN OUTCOME MEASURE: Relative risk (odds ratio) of Alzheimer's disease. RESULTS: For having history of head injury, the odds ratio was 1.52 (0.98-2.35), significant only in male patients (OR 2.1 p < 0.05). For dementias other than Alzheimer's disease the odds ratio of head injury was 2.36 and 2.46 for all dementias combined (p < 0.05). CONCLUSION: The study confirms a positive association between reported head injury and Alzheimer's disease as well as non-Alzheimer type dementia. Head trauma did not appear to be a specific risk for Alzheimer's disease as previously claimed. The association was modified by sex being only significant in male patients.<p /><p>Language: en</p>",
language="en",
issn="0885-6230",
doi="",
url="http://dx.doi.org/"
}