@article{ref1,
title="Prenatal exposure to cocaine: effects on aggression in Sprague-Dawley rats",
journal="Developmental psychobiology",
year="1994",
author="Johns, J. M. and Means, M. J. and Bass, E. W. and Means, L. W. and Zimmerman, L. I. and McMillen, B. A.",
volume="27",
number="4",
pages="227-239",
abstract="Social/aggressive behavior in adult rat offspring (beginning at postnatal Day 180) prenatally exposed to saline, cocaine, or amfonelic acid (AFA) was examined. Pregnant rats received injections of 15 mg/kg of cocaine, or 0.9% saline twice daily, s.c., or on 2 consecutive days at 4-day intervals, or 1.5 mg/kg amfonelic acid daily throughout gestational Days 1-20. Frequency, duration, and latency of 11 social/aggressive behaviors were recorded for two 15-min sessions during which a smaller male intruder replaced an ovariectomized female in the resident's home cage. Subjects received a s.c. saline injection before Session 1 and 2.0 mg/kg of gepirone, a 5HT1a partial agonist, prior to Session 2. Prenatal cocaine treatment resulted in alterations of aggressive behavior. Aggressive behavior was reduced by gepirone in all groups but to a lesser extent in the AFA group.<p /><p>Language: en</p>",
language="en",
issn="0012-1630",
doi="10.1002/dev.420270405",
url="http://dx.doi.org/10.1002/dev.420270405"
}