A brief report is made of 37,377 tests in card guessing made under conditions planned to exclude the known sensory functions from aiding in obtaining successes. The subjects were, with but few exceptions, students at Duke University. For the group, there were 1343 successes above the chance expectation. Two subjects stood out above the rest with scores about double the chance expectation. With these two, it was found that extra-sensory perception of the type displayed in the card guessing was easily interfered with by a narcotic drug, and roughly in the degree to which the drug affected the higher mental processes in general. Considerable evidence was given to show the subjects' ability voluntarily to control their responses to obtain results either above or below chance expectation. (PsycINFO Database Record (c) 2006 APA, all rights reserved)