@article{ref1,
title="The catechol o‐methyltransferase (COMT) val<sup>158</sup>met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD)",
journal="Acta psychiatrica Scandinavica",
year="2010",
author="Wagner, S. and Baskaya, Ö and Anicker, N. J. and Dahmen, N. and Lieb, K. and Tadić, A.",
volume="122",
number="2",
pages="110-117",
abstract="<p>Wagner S, Baskaya Ö, Anicker NJ, Dahmen N, Lieb K, Tadić A. The catechol o‐methyltransferase (COMT) val<sup>158</sup>met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD).</p> <p><b>Objective:</b> We analyzed i) the effects of serious life events (SLE) on impulsive aggression, and ii) modulating effects of the COMT Val<sup>158</sup>Met polymorphism on the association between SLEs and impulsive aggression in borderline personality disorder (BPD).</p> <p><b>Method:</b> One hundred and twelve female BPD patients from Germany were included in this study. Impulsive aggression was assessed by the Buss‐Durkee‐Hostility Inventory (BDHI).</p> <p><b>Results:</b> Childhood sexual abuse was associated with lower BDHI sum score (<i>P </i>= 0.003). In COMT Val<sup>158</sup>Val carriers, but not in Val/Met and Met/Met carriers, childhood sexual abuse and the cumulative number of SLEs were associated with lower BDHI sum scores (<i>P </i>< 0.05).</p> <p><b>Conclusion:</b> This study analyzing a specific gene × environment interaction in female BPD patients suggests an association between SLEs and impulsive aggression, as well as a modulating effect of the COMT Val<sup>158</sup>Val genotype on the relation between SLEs and impulsive aggression.</p><p />",
language="",
issn="0001-690X",
doi="10.1111/j.1600-0447.2009.01501.x",
url="http://dx.doi.org/10.1111/j.1600-0447.2009.01501.x"
}