@article{ref1,
title="COMT Val<sup>158</sup>Met moderation of cannabis‐induced psychosis: a momentary assessment study of ‘switching on’ hallucinations in the flow of daily life",
journal="Acta psychiatrica Scandinavica",
year="2009",
author="Henquet, C. and Rosa, A. and Delespaul, Philippe A. E. G. and Papiol, S. and Faňanás, L. and van Os, J. and Myin‐Germeys, I.",
volume="119",
number="2",
pages="156-160",
abstract="<p><b>Objective:</b> A functional polymorphism in the catechol‐<i>o</i>‐methyltransferase gene (COMT Val<sup>158</sup>Met) may moderate the psychosis‐inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted.</p> <p><b>Method:</b> The experience sampling technique was used to collect data on cannabis use and occurrence of symptoms in daily life in patients with a psychotic disorder (<i>n</i> = 31) and healthy controls (<i>n</i> = 25).</p> <p><b>Results:</b> Carriers of the COMT Val<sup>158</sup>Met Val allele, but not subjects with the Met/Met genotype, showed an increase in hallucinations after cannabis exposure, conditional on prior evidence of psychometric psychosis liability.</p> <p><b>Conclusion:</b> The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val<sup>158</sup>Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life.</p><p />",
language="",
issn="0001-690X",
doi="10.1111/j.1600-0447.2008.01265.x",
url="http://dx.doi.org/10.1111/j.1600-0447.2008.01265.x"
}