@article{ref1,
title="Clonazepam as an augmenting agent in the treatment of childhood-onset obsessive-compulsive disorder",
journal="Journal of the American Academy of Child and Adolescent Psychiatry",
year="1994",
author="Leonard, H. L. and Topol, D. and Bukstein, O. and Hindmarsh, D. and Allen, A. J. and Swedo, S. E.",
volume="33",
number="6",
pages="792-794",
abstract="This case study is of a young man with childhood onset of severe obsessive-compulsive disorder (OCD). The patient had no clinical improvement during therapeutic trials of clomipramine, fluoxetine, and fluvoxamine, including buspirone augmentation. The patient consumed 50 tablets of fluoxetine in a suicide attempt and experienced a total remission of his OCD symptoms for the first time in his life. This remission lasted approximately 1 month and raises interesting questions about the mechanism of action of the serotonin reuptake inhibitors. Subsequently, the patient was able to achieve a 75% improvement in symptomatology when treated with a combination of fluoxetine and clonazepam. This open report suggests that clonazepam may be an effective augmentation agent to a serotonin reuptake inhibitor in the treatment of OCD.<p /><p>Language: en</p>",
language="en",
issn="0890-8567",
doi="10.1097/00004583-199407000-00003",
url="http://dx.doi.org/10.1097/00004583-199407000-00003"
}