@article{ref1,
title="Sister chromatid exchanges in human peripheral blood lymphocytes after ingestion of high doses of arsenicals",
journal="International archives of occupational and environmental health",
year="1996",
author="Hantson, P. and Verellen-Dumoulin, C. and Libouton, J. M. and Leonard, A. and Leonard, E. D. and Mahieu, P.",
volume="68",
number="5",
pages="342-344",
abstract="OBJECTIVE: To evaluate the cytogenetic effects following the ingestion of high doses of arsenicals. METHODS: Determination of the mean sister chromatid exchange (SCE) frequency and the population of high-frequency cells (HFC, cells with a high SCE frequency) in the peripheral blood lymphocytes in four patients who ingested 150 mg KAsO2, 1 g, 10 g and 20 g As2O3 respectively. RESULTS: Doses of 10 g and 20 g significantly increased the HFC frequency and produced a shift in the distribution of the cells in accordance with the number of SCEs. The mean frequency of SCEs/cell was affected only after the highest dose (20 g). CONCLUSION: These results strongly suggest that cytogenetic methods are inappropriate for biomonitoring people occupationally exposed to arsenicals.<p /><p>Language: en</p>",
language="en",
issn="0340-0131",
doi="",
url="http://dx.doi.org/"
}