@article{ref1,
title="On the effect of the antidepressant viloxazin on EEG and optimization of the system driver-vehicle-road (author's transl)",
journal="Arzneimittel-Forschung",
year="1978",
author="Bente, D. and Chenchanna, P. and Scheuler, W. and Sponagel, P.",
volume="28",
number="8",
pages="1308-1310",
abstract="The effects of a single dose of 100 mg 2-[(o-ethoxyphenoxy)-methyl]-morpholine hydrochloride (viloxazin) on EEG and optimizing control behaviour of drivers were investigated under double-blind conditions in 5 male subjects with many years' driving experience. The study was carried out on a special test course using a car equipped with measuring devices. The following signals were recorded: EEG and EOG, driving speed, steering torque, steering angle and angle rate, longitudinal and lateral acceleration, and yaw rate. As evaluated by means of spectral analysis with a subsequent principal component analysis the EEG showed an increase of the power in alpha- and beta-frequencies indicating a drug induced decrease of EEG vigilance. In correspondence the optimization of the system driver-vehicle-road was reduced indicating an impairment of the driver's control behaviour.<p /><p>Language: de</p>",
language="de",
issn="0004-4172",
doi="",
url="http://dx.doi.org/"
}