@article{ref1,
title="Biochemical and clinicopathological changes induced by Bungarus coeruleus venom in a rat model",
journal="Journal of basic and clinical physiology and pharmacology",
year="2004",
author="Kiran, K. Mirajkar and More, Sunil S. and Gadag, J. R.",
volume="15",
number="3-4",
pages="277-287",
abstract="Bungarus coeruleus, a common venomous snake allied to the cobra, is responsible for most envenomations in India. This study examines the pathological effects of B. caeruleus venom and the associated biochemical changes in a rat model. Increased serum aspartate aminotransferase (48%), creatine kinase (30%), and lactate dehydrogenase (6%) were detected after a sublethal dose of 25 microg/kg of B. caeruleus venom was injected intramuscularly into rats observed for 180 min. The venom induced hyperglycemia and increased serum alkaline phosphatase (55%) and urea (90%) concentrations, whereas cholesterol and triglycerides remained normal. Histopathological changes in the heart-hemorrhage, multifocal areas of myocardial fiber necrosis-and constriction of blood vessels in the kidney, with congested vessels, hemorrhage and necrosis of proximal tubules, liver congestion, and hemorrhage were found.<p /><p>Language: en</p>",
language="en",
issn="0792-6855",
doi="",
url="http://dx.doi.org/"
}