@article{ref1,
title="Acute psychomotor, memory and subjective effects of MDMA and THC co-administration over time in healthy volunteers",
journal="Journal of psychopharmacology",
year="2011",
author="Dumont, Gjh and Van Hasselt, Jgc and de Kam, M. and van Gerven, Jma and Touw, Dj and Buitelaar, Jan and Verkes, Robbert-Jan",
volume="25",
number="4",
pages="478-489",
abstract="In Western societies a considerable percentage of young people expose themselves to the combination of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') and cannabis. The aim of the present study was to assess the acute effects of co-administration of MDMA and THC (the main psychoactive compound of cannabis) on pharmacokinetics, psychomotor performance, memory and subjective experience over time. We performed a four-way, double blind, randomized, crossover, placebo-controlled study in 16 healthy volunteers (12 male, four female) between the ages of 18 and 27. MDMA (100 mg) was given orally, THC (4, 6, and 6 mg, interval of 90 min) was vaporized and inhaled. THC induced more robust cognitive impairment compared with MDMA, and co-administration did not exacerbate single drug effects on cognitive function. However, co-administration of THC with MDMA increased desired subjective drug effects and drug strength compared with the MDMA condition, which may explain the widespread use of this combination.<p /> <p>Language: en</p>",
language="en",
issn="0269-8811",
doi="10.1177/0269881110376687",
url="http://dx.doi.org/10.1177/0269881110376687"
}