@article{ref1,
title="The Loxtox protein family in Loxosceles intermedia (Mello-Leitão) venom",
journal="Toxicon: Journal of the International Society on Toxinology",
year="2007",
author="Kalapothakis, Evanguedes and Chatzaki, M. and Gonçalves-Dornelas, H. and de Castro, C. S. and Silvestre, F. G. and Laborne, F. V. and de Moura, J. F. and Veiga, Silvio Sanches and Chávez-Olórtegui, C. and Granier, Claude and Barbaro, Katia C.",
volume="50",
number="7",
pages="938-946",
abstract="We isolated cDNA sequences coding for dermonecrotic/sphingomyelinases factor proteins from the brown spider Loxosceles intermedia, here named Loxtox proteins. The amino acid sequences based on cloned cDNA of several Loxtox proteins revealed at least six distinct groups of proteins expressed in the venom gland. The level of similarity among the toxins varied from 99% to 55%. The finding of several isoforms of Loxtox in the venom of this spider may reflect an evolutionary adaptation for different prey types and reinforces the idea of an efficient mutational mechanism in the venom gland of spiders.<p /><p>Language: en</p>",
language="en",
issn="0041-0101",
doi="10.1016/j.toxicon.2007.07.001",
url="http://dx.doi.org/10.1016/j.toxicon.2007.07.001"
}