@article{ref1,
title="Serotonin, aggression, and parental psychopathology in children with attention-deficit hyperactivity disorder",
journal="Journal of the American Academy of Child and Adolescent Psychiatry",
year="1997",
author="Halperin, J. M. and Newcorn, J. H. and Kopstein, I. and McKay, K. E. and Schwartz, S. T. and Siever, Larry J. and Sharma, V.",
volume="36",
number="10",
pages="1391-1398",
abstract="OBJECTIVE: To explore the relationship between central serotonergic (5-HT) function and history of parental aggression in aggressive and nonaggressive boys with attention-deficit hyperactivity disorder (ADHD). METHOD: History of psychiatric symptoms was assessed in the biological parents of 41 boys with ADHD. The relationship between 5-HT function in aggressive and nonaggressive probands, as assessed via the prolactin response to fenfluramine (FEN) challenge, and parental history of aggression was examined. RESULTS: Aggressive boys with a parental history of aggressive behavior had a significantly lower prolactin response to FEN challenge than aggressive boys without a parental history of aggression. Nonaggressive boys had a prolactin response midway between those of the two aggressive subgroups, and their prolactin response did not vary as a function of parental aggression. Children subdivided on the basis of parental history of other psychiatric symptoms did not differ in their response to the FEN challenge. CONCLUSIONS: These data indicate an association between parent aggressive behavior and lower 5-HT function in aggressive boys with ADHD but do not indicate the extent to which this association is environmentally and/or genetically transmitted. There may be different neurochemical mechanisms in familial and nonfamilial aggressive children, which have clinical implications for pharmacological interventions.<p /><p>Language: en</p>",
language="en",
issn="0890-8567",
doi="10.1097/00004583-199710000-00021",
url="http://dx.doi.org/10.1097/00004583-199710000-00021"
}