@article{ref1,
title="Documentation of a doxylamine overdose death: quantitation by standard addition and use of three instrumental techniques",
journal="Journal of forensic sciences",
year="1993",
author="Siek, T. J. and Dunn, W. A.",
volume="38",
number="3",
pages="713-720",
abstract="To answer the question, &quot;Is this death due to a drug overdose?&quot; requires at least that the drug be unequivocally identified and a blood concentration reliably determined. The approach taken in this case as standard addition technique and use of three different chromatographic techniques-high performance liquid chromatography (HPLC), high performance thin-layer chromatography (HP-TLC) and gas chromatography/mass spectrometry (GC/MS). Each of the chromatographies was carried out on the same extract by splitting the residue three ways. HPLC provided a quantitative result which was 1.2 mg/L in blood and HP-TLC and GC/MS confirmed this result with additional quantitative data, information about two metabolites (nordoxylamine and dinordoxylamine) and conclusive identification. Blood nordoxylamine was 0.52 mg/L and doxylamine plus metabolites in urine was 25 mg/L.<p /><p>Language: en</p>",
language="en",
issn="0022-1198",
doi="",
url="http://dx.doi.org/"
}