@article{ref1,
title="Case study: paradoxical response to naltrexone treatment of self-injurious behavior",
journal="Journal of the American Academy of Child and Adolescent Psychiatry",
year="1995",
author="Benjamin, S. and Seek, A. and Tresise, L. and Price, E. and Gagnon, M.",
volume="34",
number="2",
pages="238-242",
abstract="Opioid receptor antagonists have been studied in the management of self-injurious behavior (SIB) in developmentally disabled individuals. The authors present a case of a severely retarded, autistic man whose SIB increased dramatically during a trial of naltrexone. A paradoxical increase in SIB, attributed to the extinction burst phenomenon during the initial period of nonreward, is known to occur during treatment with naloxone, a short-acting parenteral opioid antagonist. It has only once been reported during treatment with naltrexone, a long-acting orally administered agent. Opioid analgesic effects and learning theory can explain both increases and decreases in SIB after opioid blockade.<p /><p>Language: en</p>",
language="en",
issn="0890-8567",
doi="10.1097/00004583-199502000-00020",
url="http://dx.doi.org/10.1097/00004583-199502000-00020"
}