@article{ref1,
title="Regional macrophage activation after injury and the compartmentalization of inflammation in trauma",
journal="New horizons",
year="1996",
author="Hauser, C. J.",
volume="4",
number="2",
pages="235-251",
abstract="The mononuclear phagocyte or macrophage (M phi) system is an important early participant in the human immune response to injury. M phi are uniquely able to transduce a broad variety of nonspecific physical and chemical stimuli generated in traumatized tissues as well as specific immune signals (such as cytokines) into coherent response patterns. Thus, M phi occupy a central position in the overall response in that they can initiate specific, cognate immune responses to injury. M phi are both responsive to cytokine signals and key inducers of cytokine-mediated patterns of response in other cells. Not only do the responses of M phi in different diseases states very widely, but these responses may vary from location to location and over time in the same organism. This article examines the role of M phi in the response to injury, focusing on local activities and the hypothesis that local M phi response patterns (and their pathologic loss) may be involved in the generation of immune-mediated organ injury distant from sites of direct trauma.<p /><p>Language: en</p>",
language="en",
issn="1063-7389",
doi="",
url="http://dx.doi.org/"
}