@article{ref1,
title="Dilantin toxicity as a possible cause of major depression",
journal="Harefuah",
year="1993",
author="Levkovitch, Y. and Abramovitch, Y. and Nizan, I.",
volume="124",
number="12",
pages="762-4, 795",
abstract="Diphenylhydantoin (D; Dilantin) is widely used in neurologic and psychiatric practice for treating convulsive disorders. D overdosage and poisoning may cause behavioral disturbances, such as schizophreniform and delusional states. To the best of our knowledge, D has been linked with mood disorders in just 1 documented case. We report a 70-year-old woman who developed major depression as a complication of D intoxication. Treatment with folic acid led to complete recovery. We believe that D causes depression by lowering folic acid blood levels by a biochemical mechanism. We suggest that levels of D and folic acid be monitored continually all patients treated with the drug.<p /><p>Language: he</p>",
language="he",
issn="0017-7768",
doi="",
url="http://dx.doi.org/"
}