@article{ref1,
title="Suicide inhibition of monoamine oxidases A and B by (-)-deprenyl. A computer-aided solution for determining inhibition specificity",
journal="Biochemical pharmacology",
year="1993",
author="Batke, J. and Gaal, John",
volume="46",
number="4",
pages="597-602",
abstract="An analytical solution to the differential equations describing the kinetics of the suicide inhibition of a two-enzyme system has been derived and the modelling of suicide inhibition of the monoamine oxidases A and B (MAO A and B, EC 1.4.3.4) by a quasi-selective agent, (-)-deprenyl, is presented as an example. A new parameter, the specificity index is defined and used in a model which describes the specific and non-specific binding of (-)-deprenyl to MAO B and MAO A, respectively. This type of analysis may be of therapeutic value by indicating optimal dosage of quasi-selective MAO B inhibitors for the treatment of Parkinson's disease.<p /><p>Language: en</p>",
language="en",
issn="0006-2952",
doi="",
url="http://dx.doi.org/"
}