@article{ref1,
title="Effects of antiepileptic drugs on reaction time, attention, and impulsivity in children",
journal="Pediatrics",
year="1993",
author="Mitchell, W. G. and Zhou, Y. and Chavez, J. M. and Guzman, B. L.",
volume="91",
number="1",
pages="101-105",
abstract="Simple, choice, and complex reaction times, attention (variability of responses and omission errors), and impulsivity (commission and wrong-hand errors on choice and complex reaction time) were repeatedly measured in 111 epileptic children, aged 5 to 13 years, tested a total of 232 times. Antiepileptic drugs (AEDs) were started, stopped, and adjusted throughout the study period, for a variety of clinical indications, and AED serum levels were monitored. The relationship of performance to AED serum level was examined. Overall the nonspecific effect of AEDs was minimal: higher total serum levels of AEDs correlated with more impulsive errors on complex reaction time testing only. In contrast, in 54 children receiving carbamazepine monotherapy, we found a dose-related beneficial effect upon reaction time, with higher serum levels associated with faster responses and fewer omission errors, particularly on complex reaction time. Phenobarbital caused minimal dose-related effects: only variability and impulsive errors increased with increasing serum levels, and only on one segment of the test (73 subjects).<p /><p>Language: en</p>",
language="en",
issn="0031-4005",
doi="",
url="http://dx.doi.org/"
}