@article{ref1,
title="The enhancement of contextual fear conditioning by ABT-418",
journal="Behavioural pharmacology",
year="2010",
author="Kenney, Justin W. and Wilkinson, Derek S. and Gould, Thomas J.",
volume="21",
number="3",
pages="246-249",
abstract="Activation of nicotinic acetylcholine receptors (nAChRs) is known to modulate various forms of learning and memory, including contextual fear conditioning. Although numerous studies have shown that high-affinity beta2-containing nAChRs are necessary for the nicotine-induced enhancement of contextual fear conditioning, it is unknown whether other high-affinity nAChR agonists are capable of enhancing this learning. To examine this issue, ABT-418, a high-affinity nAChR agonist with greater selectivity for high-affinity receptors than nicotine, was administered before acquisition and/or recall of contextual fear memories. ABT-418 enhanced acquisition of contextual fear memories in a dose-dependent manner.<p /> <p>Language: en</p>",
language="en",
issn="0955-8810",
doi="10.1097/FBP.0b013e32833a5b9d",
url="http://dx.doi.org/10.1097/FBP.0b013e32833a5b9d"
}