@article{ref1,
title="Apoptosis in subicular neurons: A comparison between suicide and Addison's disease",
journal="Indian journal of psychiatry",
year="2009",
author="Printha, K. and Hulathduwa, Sanjaya R. and Samarasinghe, K. and Suh, Y. H. and De Silva, K. R. D.",
volume="51",
number="4",
pages="276-279",
abstract="Background: Stress and depression shows possible links to neuronal death in hippocampus. Subiculum plays a prominent role in limbic stress integration and direct effect of corticosteroids on subicular neurons needs to be defined to assess its subsequent impact on hippocampal plasticity. Aim: This study was intended to assess apoptosis in subicular neurons of a young depressed suicide victim, where presumably stress induced excess of corticosteroids and a case of young Addison's disease with low level of corticosteroids. Materials and Method: Both bilateral adrenal glands (Addison's) and subiculum (both cases) were initially stained with hematoxylin and eosin; subicular neurons of both cases were examined for the degree of apoptosis using 'ApopTag Kit'. Apoptotic cell counts were expressed as average number of labeled cells/mm 2 and the results were analysed statistically using a non-parametric Mann-Whitney U test. Result: Apoptotic neurons were detected in the subicular region of both suicide and Addison victims, and it is statistically significant in both right and left between the cases (P < 0.05). In suicide victim, the neuronal apoptosis is considerably significant between the two hemispheres (P < 0.05), in contrast to Addison disease where the number of neuronal cell death between right and left was statistically insignificant (P > 0.05). Conclusion: The present study confirms the vulnerability of the subicular neurons to apoptosis, possibly due to corticosteroids in both ends of spectrum.<p /> <p>Language: en</p>",
language="en",
issn="0019-5545",
doi="10.4103/0019-5545.58293",
url="http://dx.doi.org/10.4103/0019-5545.58293"
}