@article{ref1,
title="REM sleep without Atonia in Narcolepsy",
journal="Neuro endocrinology letters",
year="2009",
author="Buskova, Jitka and Nevsimalova, Sona and Kemlink, David and Sonka, Karel",
volume="30",
number="6",
pages="-",
abstract="Objectives: While there are a number of observations/quantifications indicating a greater proportion of REM sleep without atonia (RWA) in narcolepsy, the intra-night distribution of this parameter has not been evaluated. Material and methods: Thirty-four patients (15 men and 19 women; mean age 44.9 +/- 18.9) with narcolepsy-cataplexy were included in this retrospective study. The clinical diagnosis was confirmed by MSLT, video-polysomnography and HLA typing. Polysomnographic recordings were scored with particular regard to REM sleep without atonia (RWA) across all the nocturnal REM periods. RWA scoring was done according to a standard method. Results: The analysis showed a significant increase in the proportion of REM sleep without atonia during successive nocturnal REM periods in narcoleptic patients (p<0.01). No correlation was found between the percentage of RWA and the severity or duration of the disease, no age effect was documented. Conclusion: The study demonstrates for the first time an increasing amount of RWA during the night suggesting enhanced nocturnal REM sleep motor disturbance.<p /> <p>Language: en</p>",
language="en",
issn="0172-780X",
doi="",
url="http://dx.doi.org/"
}