@article{ref1,
title="Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment",
journal="Journal of the American Academy of Child and Adolescent Psychiatry",
year="1991",
author="King, Robert A. and Riddle, M. A. and Chappell, P. B. and Hardin, M. T. and Anderson, George M. and Lombroso, P. and Scahill, L.",
volume="30",
number="2",
pages="179-186",
abstract="Self-injurious ideation or behavior appeared de novo or intensified during fluoxetine treatment of obsessive-compulsive disorder in six patients, age 10 to 17 years old, who were among 42 young patients receiving fluoxetine for obsessive-compulsive disorder at a university clinical research center. These symptoms required the hospitalization of four patients. Before receiving fluoxetine, four patients had major risk factors for self-destructive behavior including depression or prior suicidal ideation or self-injury. Three hypotheses concerning the apparent association between fluoxetine and these self-injurious phenomena are discussed: (1) coincidence; (2) disorganization of vulnerable individuals secondary to drug-induced activation; and (3) a specific serotonergic-mediated effect on the regulation of aggression.<p /> <p>Language: en</p>",
language="en",
issn="0890-8567",
doi="",
url="http://dx.doi.org/"
}