@article{ref1,
title="An apparent fatal valproic acid poisoning",
journal="Journal of analytical toxicology",
year="1988",
author="Lokan, R. J. and Dinan, A. C.",
volume="12",
number="1",
pages="35-37",
abstract="While extensive data on therapeutic concentrations of valproic acid in plasma exist, data on toxic or fatal levels are very limited and superficial, interpretation of isolated blood levels obtained post-mortem is therefore a difficult task. A case of sudden death is described here. The circumstances are known and strongly indicate a fatal, suicidal poisoning by valproic acid at a dose of 56.4 g. Valproic acid was quantified in tissues by gas chromatography, and its identity confirmed by gas chromatography/mass spectrometry. The tissue concentrations found post-mortem were as follows: blood 720 mg/L; liver 800 mg/kg; stomach contents 1700 mg. Phenobarbitone and propoxyphene were also present at therapeutic concentrations. This data should provide a useful reference for interpretive purposes.<p /> <p>Language: en</p>",
language="en",
issn="0146-4760",
doi="",
url="http://dx.doi.org/"
}