@article{ref1,
title="Benzodiazepine receptor and neurotransmitter studies in the brain of suicides",
journal="Life Sciences",
year="1987",
author="Manchon, M. and Kopp, N. and Rouzioux, J. J. and Lecestre, D. and Deluermoz, S. and Miachon, S.",
volume="41",
number="24",
pages="2623-2630",
abstract="The characteristics of benzodiazepine binding sites (affinity, number heterogeneity) were studied on frozen sections of hippocampus of 7 suicides and 5 controls subjects, using biochemical and autoradiographic techniques. 3H flunitrazepam was used as ligand, clonazepam and CL 218,872 as displacing agents. Some neurotransmitters or their derivatives (GABA, catecholamines, hydroxy-indols) were evaluated quantitatively in parallel in the hippocampal tissue by liquid chromatography. We observed mainly an increase in the Ki of CL 218,872 subtype I binding sites in suicides, (7.48 +/- 1.7 to 17.24 +/- 1.7 nM, P less than 0.01), (m +/- SEM) and an increase in % of type I binding sites (30 +/- 4.2 to 42 +/- 2.5, P = 0.01). Among neurotransmitters, only norepinephrine differed significantly between controls and suicides (11.34 +/- 1.9 to 24.34 ng/g tissue, P = 0.02).<p /><p>Language: en</p>",
language="en",
issn="0024-3205",
doi="",
url="http://dx.doi.org/"
}