@article{ref1,
title="Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene",
journal="Journal of affective disorders",
year="2006",
author="Giegling, Ina and Hartmann, Annette M. and Moller, Hans-Jurgen and Rujescu, Dan",
volume="96",
number="1-2",
pages="75-81",
abstract="BACKGROUND: This study investigates the association of four single nucleotide polymorphisms (SNPs) in the serotonin 2A (5-HT-2A) receptor gene with anger-, aggression- and suicide-related behavior in a total of 566 subjects (203 German suicide attempters and 363 German community-based healthy volunteers). METHODS: Anger- and aggression-related traits were assessed by using the State Trait Anger Expression Inventory (STAXI) and the Questionnaire for Measuring Factors of Aggression (FAF). RESULTS: Three (rs643627-rs594242-rs6311: A-C-T), two (rs594242-rs6311: C-T) and a single functional (rs6311: T) marker were protective against suicidal behavior. The complementary makers (rs594242-rs6311: G-C and rs6311: C) were associated with increased risk for non-violent (p=0.01; p=0.009 respectively) and impulsive suicidal behavior (p=0.03; p=0.01 respectively). Furthermore, CC-homozygotes for the functional SNP rs6311 reported more anger- (p=0.004) and aggression-related behavior (p=0.011). CONCLUSION: We conclude that variations in the 5-HT-2A gene may modify the phenotype of suicide-, anger-, and aggression-related behavior. Further studies should especially focus on intermediate personality traits in this context.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2006.05.016",
url="http://dx.doi.org/10.1016/j.jad.2006.05.016"
}